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Heterogeneous expression of B7-H3 and IDO1 in osteosarcoma tissue. (A, C) Representative images of (A) B7-H3 and (C) IDO1 immunohistochemistry demonstrating immunoreactivity in malignant cells and tumor-associated vasculature. (B, D) Variable expression of (B) B7-H3 and (D) IDO1 in lymphoid aggregates. Black boxes indicate enlarged regions of interest (to the right of each panel). Black arrows denote tumor vasculature. Scale bar = 50#181;m.
