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. 2018 Dec 3;62(5):643–723. doi: 10.1042/EBC20170053

Figure 9. The XIC.

Figure 9

A simplified view of genes located at the XIC (not to scale), which maps at Xq13.2 on the human X chromosome and spans over 1 Mb. XIST (red) is surrounded by a number of other non-coding RNA genes (blue), which have an effect upon XIST regulation, including TSIX. Additionally, there are protein encoding genes (yellow), within the XIC region and recently RLIM has been shown to regulate XIST expression. Deletions across this region affect the process of X chromosome inactivation, but the function of all the genes and sequence regions located at XIC are yet to be fully understood.