Table 1.
Precancer Cases (n = 72) | Controls (n = 72) * | p value | |
---|---|---|---|
Age, median (IQR) | 38.4 (34.0–45.4) | 36.6 (32.5–42.0) | 0.08 |
Race, n (%) | 0.98 | ||
Black | 44 (61) | 45 (63) | |
Hispanic | 21 (29) | 20 (28) | |
White | 7 (10) | 7 (10) | |
Other | 0 (0) | 0 (0) | |
Risk factors | |||
Lifetime number of sex partners, median (IQR) | 10 (5–50) | 20 (6–100) | 0.16 |
Number of sex partners past 6 months, median (IQR) | 1 (0–1) | 1 (0–1) | 0.09 |
Parity, median (IQR) | 3 (1–4) | 2 (1–3) | 0.03 |
Current Smoking, n (%) | 48 (67) | 39 (54) | 0.13 |
Hierarchical HPV genotype, n (%)** | 1.00 | ||
HPV16 | 19 (26) | 19 (26) | |
HPV18 | 11 (15) | 11 (15) | |
Other high risk (HR) HPV (no HPV16 or 18) | 42 (58) | 42 (58) | |
Multiple HR-HPV Types, n (%)*** | 23 (32) | 9 (13%) | 0.01 |
CD4 count, median (IQR) | 237 (133–456) | 278 (149–454) | 0.71 |
Controls had no CIN2 or greater at any time in the WIHS Study, and were matched to cases based on age, CD4 count, and HPV.
HPV16 > HPV18 > other HPV types. Approximately 32% (23/72) of cases and 13% (9/72) had multiple HR-HPV infections (i.e., ≥ 2 HR-HPV types).
Details of cases and controls with multiple HR-HPV types are shown in Figure 3.