Table 1:
Characteristics of 157 subjects undergoing iWITH eligibility biopsy
| Characteristic* | ||||
|---|---|---|---|---|
| Donor | Age (years) | 15.7 (15.44) | ||
| Male gender | 81 (51.6) | |||
| Race (n=132) | White | 105 (79.5) | ||
| Black | 19 (14.4) | |||
| Other | 8 (6.1) | |||
| Deceased | 110 (70.1) | |||
| Recipient | Age at transplant (years) | 1.8 (1.70) | ||
| Male gender | 79 (50.3) | |||
| Race (n=152) | White | 128 (84.2) | ||
| Black | 11 (7.2) | |||
| Other | 13 (8.6) | |||
| Transplant indication | Acute Liver Failure | 11 (7.0) | ||
| Biliary Atresia | 86 (54.8) | |||
| Tumor | 8 (5.1) | |||
| Metabolic Liver Disease | 18 (11.5) | |||
| Other | 34 (21.7) | |||
| Transplant | Whole graft | 73 (46.5) | ||
| Previous rejection episodes | 0 | 96 (61.1) | ||
| 1 | 40 (25.5) | |||
| 2 or more | 21 (13.4) | |||
| Time since last rejection (years) | 7.3 (3.22) | |||
| At Study Entry | Age (years) | 10.7 (3.50) | ||
| Time since transplant (years) | 8.9 (3.46) | |||
| ALT (U/L) | 27.6 (14.57) | |||
| GGT (U/L) | 17.4 (7.93) | |||
| Quantitative IgG (n=125; mg/dL) | 701.0 (194.95) | |||
| ANA ≥1:40 (n=133) | 34 (25.6) | |||
| ASMA = 1:80 (n=133) | 5 (3.8) | |||
| α-AT1R antibody (n=119; U/mL) | 35.9 (21.49) | |||
| α-ETAR antibody (n=119; U/mL) | 35.2 (21.39) | |||
| Class II DSA positive (n=144; MFI ≥2,000) | 80 (55.6) | |||
| Class II DSA (n=80) | Number of DSAs | 1 | 42 (52.5) | |
| 2 | 28 (35.0) | |||
| 3 or more | 10 (12.5) | |||
| Maximum MFI >20,000 | 37 (46.2) | |||
| MFI sum >20,000 | 45 (56.2) | |||
*
Continuous variables are summarized using mean and standard deviation (SD). Categorical variables are summarized by counts and percentages.