Table 2:
Clinical and serological factors associated with assignment into cluster 1
| Characteristic | Reference | OR | 95% CI | P Value | ||
|---|---|---|---|---|---|---|
| Univariable | ||||||
| Donor | Age (per year) | 0.98 | 0.95–1.01 | 0.14 | ||
| Deceased | Living | 4.03 | 1.33–12.20 | 0.01 | ||
| Recipient | Female | Male | 0.47 | 0.21–1.04 | 0.06 | |
| Biliary Atresia | Other | 0.42 | 0.19–0.93 | 0.03 | ||
| Transplant | Whole graft | Partial graft | 1.89 | 0.87–4.08 | 0.11 | |
| Whole graft | Living graft | 4.06 | 1.29–12.77 | 0.02 | ||
| Deceased partial graft | 3.98 | 1.14–13.97 | 0.03 | |||
| Induction immunosuppression | None | 0.55 | 0.15–1.99 | 0.36 | ||
| Study Entry | Recipient age (per year) | 0.90 | 0.81–1.01 | 0.07 | ||
| Time since transplant (per year) | 0.88 | 0.78–0.99 | 0.03 | |||
| ALT (per U/L) | 1.06 | 1.02–1.11 | 0.009 | |||
| GGT (per U/L) | 1.02 | 0.97–1.06 | 0.51 | |||
| ANA ≥ 1:40 | Negative | 1.62 | 0.65–4.05 | 0.30 | ||
| ASMA = 1:80 | Negative | 0.98 | 0.10–9.15 | 0.99 | ||
| α-AT1R antibody (per U/mL) | 1.03 | 1.01–1.05 | 0.01 | |||
| α-ETAR antibody (per U/mL) | 1.03 | 1.00–1.05 | 0.02 | |||
| Class II DSA | Positive | Negative | 2.90 | 1.14–7.34 | 0.02 | |
| Maximum MFI ≤ 20,000 | No class II DSA | 1.32 | 0.41–4.24 | 0.64 | ||
| Maximum MFI > 20,000 | 5.55 | 2.00–15.44 | 0.001 | |||
| MFI sum ≤ 20,000 | No class II DSA | 1.36 | 0.40–4.64 | 0.63 | ||
| MFI sum > 20,000 | 4.49 | 1.67–12.14 | 0.003 | |||
| Multivariable | ||||||
| ALT (per U/L) | 1.07 | 1.02–1.13 | 0.01 | |||
| Class II DSA | MFI sum ≤ 20,000 | No class II DSA | 1.50 | 0.43–5.26 | 0.53 | |
| 5.11 | 1.82–14.41 | 0.002 | ||||
| MFI sum > 20,000 | ||||||