. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Ann Biomed Eng. 2018 Jul 9;46(11):1938–1950. doi: 10.1007/s10439-018-2086-7

Table 2. Parameters for collagen and smooth muscle cells, found from experiments or the literature^27,28, which are used as inputs to the computational G&R model.

Native Vein Mechanical Fitting
Parameter	Description	Value	Units
$c_{1, h}^{c}$	C57BL/6 collagen material parameter 1	4.2	kPa
$c_{2, h}^{c}$	C57BL/6 collagen material parameter 2	0.1	(−)
$c_{1, h}^{s m}$	C57BL/6 SMC material parameter 1	1.68	kPa
$c_{2, h}^{s m}$	C57BL/6 SMC material parameter 2	0.36	(−)
$c_{1, h}^{c}$	SCID/bg collagen material parameter 1	2	kPa
$c_{2, h}^{c}$	SCID/bg collagen material parameter 2	0.5	(−)
$c_{1, h}^{s m}$	SCID/bg SMC material parameter 1	3.1	kPa
$c_{2, h}^{s m}$	SCID/bg SMC material parameter 2	3.15	(−)
Prior G&R Simulations
Parameter	Description	Value	Units
$m_{h}^{m, c}$	basal collagen production rate	0.123	mg/(m²·days)
$k_{h}^{m, c}$	basal collagen degradation rate³⁴	1/80	days
$m_{h}^{m, s m}$	basal SMC production rate	0.131	mg/(m²·days)
$k_{h}^{m, s m}$	basal SMC degradation rate³⁴	1/80	days
$K_{σ}^{m}$	production gain from circumferential stress²⁴	1	(−)
$K_{τ_{w}}^{m}$	production gain from wall shear stress²⁵	5	(−)
$K_{w}^{i}$	baseline wounding response²⁵	5	(−)
r_n	critical pore size⁸	10	μm

Table 2. Parameters for collagen and smooth muscle cells, found from experiments or the literature27,28, which are used as inputs to the computational G&R model.