Table 5. Association between Family History and Total Prostate Cancer Risk stratified by a Man’s Age.
| Age <60 |
Age ≥60 |
|||
|---|---|---|---|---|
| Variable | Cases Unexposed/ exposed |
Multivariable Hazard Ratioa (95% CI) |
Cases Unexposed/ exposed |
Multivariable Hazard Ratioa (95% CI) |
| Overall family historyb | ||||
| None | ||||
| Breast cancer only | 270/54 | 1.62 (1.20, 2.18) | 2,801/406 | 1.17 (1.06, 1.30) |
| Prostate cancer only | 270/66 | 2.19 (1.67, 2.88) | 2,801/516 | 1.63 (1.48, 1.79) |
| Breast and prostate cancer | 270/13 | 2.44 (1.39, 4.29) | 2,801/82 | 1.52 (1.22, 1.91) |
| Breast cancer family historyc | ||||
| None | ||||
| Mother only | 336/54 | 1.55 (1.15, 2.08) | 3,317/280 | 1.08 (0.96, 1.23 |
| Sister only | 336/11 | 1.36 (0.74, 2.51) | 3,317/184 | 1.19 (1.02, 1.38) |
| Mother & Sister | 336/2 | 1.52 (0.37, 6.17) | 3,317/24 | 1.20 (0.80, 1.80) |
| Age of mother or sister at breast cancer diagnosisd | ||||
| No breast cancer family history | ||||
| <60 years | 336/29 | 1.39 (0.94, 2.05 | 3,317/253 | 1.24 (1.09, 1.41) |
| ≥60 years | 336/32 | 1.65 (1.14, 2.40) | 3,317/183 | 0.97 (0.83, 1.12) |
| Age unknown | 336/6 | 1.44 (0.63, 3.31) | 3,317/52 | 1.31 (0.99, 1.73) |
| Prostate cancer family historye | ||||
| None | ||||
| Father only | 324/75 | 2.09 (1.62, 2.70) | 3,207/439 | 1.59 (1.44, 1.76) |
| Brother only | 324/4 | 2.32 (0.84, 6.35) | 3,207/134 | 1.48 (1.24, 1.77) |
| Father & Brother | 324/0 | N/A | 3,207/25 | 1.80 (1.20, 2.69) |
| Age of father or brother at prostate cancer diagnosisf | ||||
| No prostate cancer family history | ||||
| <60 years | 324/10 | 3.36 (1.77, 6.37) | 3,207/63 | 1.65 (1.28, 2.13) |
| ≥60 years | 324/58 | 1.91 (1.44, 2.54) | 3,207/455 | 1.55 (1.40, 1.71) |
| Age unknown | 324/11 | 2.34 (1.27, 4.30) | 3,207/80 | 1.66 (1.32, 2.08) |
Multivariable Hazard Ratio adjusted for: age, race (White, Black, Asian, other), body mass index, smoking status (never smoker, past smoker who quit >10 years ago, past smoker who quit ≤10 years ago, current smoker), PSA screening (yes/no in prior questionnaire cycle), PSA testing intensity (variable indicating subjects who had testing in >50% of time periods), alcohol intake, vigorous physical activity, total energy intake, consumption of tomato sauce, and red meat.
Overall family history-age interaction: p-value = 0.04.
Breast cancer family history-age interaction: p-value = 0.18.
Age of relative at breast cancer diagnosis-age interaction: p-value = 0.07.
Prostate cancer family history-age interaction: p-value = 0.23.
Age of relative at prostate cancer diagnosis-age interaction: p-value = 0.09.
Follow-up: 254,626 person-years, 1996–2012.