. 2018 Oct 23;26(2):179–190. doi: 10.1007/s40199-018-0223-3

Table 2.

Effects of H. nepalensis crude extract and lupeol on cortex, cerebellum and liver antioxidant activity

Organ	Treatment	Protein (μg/mg tissue)	TBARS (nM/min/ mg tissue)	CAT (U/min)	SOD (U/mg protein)	GSH (mM/g tissue)
Cortex	NC	0.97 ± 0.09	9.09 ± 0.9	4.4 ± 0.11	1.2 ± 0.01	6.2 ± 0.36
	PC	0.65 ± 0.08^NS	14.5 ± 2.1^NS	3.7 ± 0.06^***	1.02 ± 0.01^**	4.9 ± 0.25^NS
	AC	0.56 ± 0.14^*	22 ± 2.9^***	2.5 ± 0.09^***	0.5 ± 0.06^***	1.6 ± 0.18^***
	AC + HNC	1.06 ± 0.11^NS	7.94 ± 1.4^NS	4.3 ± 0.08^NS	1.6 ± 0.01^***	6.3 ± 0.61^NS
	AC + lupeol	1.04 ± 0.19^NS	6.44 ± 1.21^NS	3.1 ± 0.08^***	1.9 ± 0.01^***	7.6 ± 0.48^NS
Cerebellum	NC	0.77 ± 0.07	12.7 ± 1.5	5.0 ± 0.05	1.1 ± 0.01	4 ± 0.53
	PC	0.83 ± 0.09^NS	11.0 ± 1.5^NS	4.2 ± 0.03^***	0.7 ± 0.16^**	3.7 ± 0.34^NS
	AC	0.38 ± 0.07^*	27.7 ± 2.4^***	3.2 ± 0.03^***	0.3 ± 0.02^***	2.8 ± 0.22^NS
	AC + HNC	0.93 ± 0.09^NS	12.8 ± 1.51^NS	4.8 ± 0.09^*	1.2 ± 0.003^NS	4.01 ± 0.45^NS
	AC + lupeol	0.88 ± 0.13^NS	7.71 ± 1.3^NS	3.9 ± 0.03^***	1.3 ± 0.02^NS	3.07 ± 0.28^NS
Liver	NC	5.41 ± 0.40	10.0 ± 1.2	12.3 ± 0.33	4.2 ± 0.01	14.7 ± 0.41
	PC	5.43 ± 0.28^NS	8.44 ± 2.14^NS	13.0 ± 0.15^NS	3.03 ± 0.01^***	12.0 ± 0.60^NS
	AC	3.27 ± 0.12^**	12.8 ± 1.9^***	9.8 ± 0.08^***	1.3 ± 0.09^***	8.8 ± 0.76^***
	AC + HNC	6.34 ± 0.6^NS	8.76 ± 2.0^NS	14.1 ± 0.17^***	3.9 ± 0.09^*	15.5 ± 0.64^NS
	AC + lupeol	5.85 ± 0.62^NS	6.58 ± 1.6^NS	11.5 ± 0.4^NS	4.5 ± 0.11^*	16.8 ± 1.12^NS

Where “NC” is normal control, “PC” is positive control (Rivastigmine), “AC” is Alzheimer control and “HNC” is H. nepalensis crude extract. Values are *p < 0.05, **p < 0.01 and *** p < 0.01 statistically significant as compared to AC group expressed as means ± SEM whereas ^NS represents non-significant