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. 2018 Nov 13;21:2323–2329. doi: 10.1016/j.dib.2018.11.042

Fig. 1.

Fig. 1

Expression of Sirt1 and Pten within the forebrain of WT, miR-132/212 cKO, and miR-132 transgenic animals (top three rows). Representative 10X immunofluorescent images of Sirt1 in the hippocampus (A) and amygdala (B). Representative 10X immunofluorescent images of Pten in the hippocampus (C) and amygdala (D). Immunolabeling in miR-132 transgenic animals maintained on doxycycline is also shown (bottom row). Note the increased and decreased target gene expression in miR-132/212 cKO and miR-132 transgenic animals, respectively, relative to WT mice. Also note the decreased expression of CFP in the miR-132 transgenic animals maintained on doxycycline, in addition to the subtle increase in Sirt1 and Pten expression in miR-132 transgenic animals on doxycycline relative to miR-132 transgenic animals not maintained on doxycycline. CFP is a marker for the miR-132 transgenic mouse line, and as such, immunofluorescence was not observed in WT and miR-132/212 cKO animals. Scale bar = 300 μm for both hippocampal and amygdalar images. Abbreviations: CA1-cornu ammonis 1 hippocampal subfield; GCL-granule cell layer; LA-lateral amygdala; BLA-basolateral amygdala; CeA-central amygdala.