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. 2018 Dec 4;8:17626. doi: 10.1038/s41598-018-35858-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depiction of in silico modeling and analysis of an MPS system. Optical measurements of calcium and voltage are taken at baseline and in the presence of drug. These waveforms are inverted using a mathematical model of cell dynamics, into a set of parameters that define key ion channel conductances. Changes in this parameter set give information about specific changes in conductances under drug, and this parameter set can then be mapped to a model of mature cell behavior using the assumption of functional invariance of individual channels.