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. 2018 Dec 4;8:17626. doi: 10.1038/s41598-018-35858-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of the assumptions underlying our model of maturation. (A) The immature cell with two types of membrane proteins, with a cytosolic space containing the sarcoplasmic reticulum with associated release and uptake proteins. (B) Maturation is multiplication in the sense that the number of proteins increases at a protein specific rate. (C) A specific protein in the IM cell is the same as in the M cell. (D) A drug affects every single protein in the IM cell in exactly the same manner as for the M cell. (E) Model of the transmembrane potential for IM and M cells, and the relation between these models; and how these models are affected when a drug is applied.