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PD-L1/PD-1 signaling pathway and the correlated network. Interaction between PD-L1 and PD-1 on T cells results in inhibition of Zap70 phosphorylation and PI3K activation, and finally attenuates TCR signaling, CD28 mediated co-stimulation, NF-κB, and AP-1 activation, and IL2 production. Through inhibition of T cell via overexpression of PD-L1, cancer cells evade the host immune system.
