Table 5.

Management of treatment-related rash, pneumonitis, thyroid dysfunction and diarrhea (100).

Adverse events	Grade 1–2	Grade 3–4
Rash	≤30% BSA: anti-histamines for pruritus and topical steroid cream for rash.	>30% BSA:skin biopsy is needed and steroids with 1 mg/kg of prednisolone until BSA≤30%.If life-threatening, permanently discontinue drug administration.
Pneumonitis	Clinical or diagnostic observations; delay drug administration; daily monitoring.	Oxygen is needed; stop drug administration; hospitalization; high dose steroids with methylprednisolone; intensive care support.
Thyroid dysfunction	Clinical or diagnostic observations; daily monitoring; for hypothyroidism, levothyroxine indicated; for hyperthyroidism, propranolol is needed.	Hospitalization; specialist consult; clinical observation
Diarrhea	≤6 bowel actions/day: supportive measures; anti-motility agents when needed.	>7 bowel actions/day: hospitalization; specialist consult; clinical observation; steroids with 1–2mg/kg prednisolone.