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. 2018 Nov 28;9:1623. doi: 10.3389/fphys.2018.01623

FIGURE 4.

FIGURE 4

IS-induced changes in hemostatic parameters: PF4 (A), vWF (B), TF (C), TF/VII complex (D), FV (E), FXa (F), TAFI (G), PAI-1 (H), PAP (I), and d-dimers (J). Data are presented as the mean ± SD or median (full range) depending on their distribution. CON, control group; 100 IS, group receiving IS in the dose of 100 mg/kg b.w./day; 200 IS, group receiving IS in the dose of 200 mg/kg b.w./day; IS, indoxyl sulfate; PF4, platelet factor 4; vWF, von Willebrand factor; FV, coagulation factor V; FXa, activated coagulation factor X; TF, tissue factor; TF/VII complex, TF/coagulation factor VII complex; TAFI, thrombin activatable fibrinolysis inhibitor; PAI-1, plasminogen activator inhibitor-1; PAP, plasmin-alpha2-antiplasmin complex; p < 0.05 compared to control; ∗∗p < 0.01 compared to control; ∗∗∗p < 0.001 compared to control; #p < 0.05 compared to 100 IS group.