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. 2018 Nov 1;12:71–84. doi: 10.1016/j.omtm.2018.10.016

Table 1.

Quantitative Comparison of Shuffling Efficiency between AAV Libraries Generated Using Standard and lcoAAV Inputs

AAVLib1-12 AAVLiblco1–12 AAVLib1–12+EM AAVLiblco1–12+EM
Plasmid Library

Number of parental segments per clone 17.77 ± 4.77 16.97 ± 3.09 14.57 ± 4.71 16.77 ± 3.21
Average length of donor segments (bp) 118.9 122.12 140.8 126
Number of parental variants contributing 8.03 ± 1.14 9.73 ± 1.12 7.87 ± 1.43 10.17 ± 1.57

Packaged AAV Library

Number of parental segments per clone 19.66 ± 3.87 15.91 ± 3.78 16.50 ± 3.84 17.00 ± 4.93
Average length of donor segments (bp) 130.32 138.43 124.61 135.44
Number of parental variants contributing 7.17 ± 1.52 9.01 ± 1.38 6.41 ± 1.93 9.30 ± 1.87