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. 2015 Jan 19;11(4):109–112. doi: 10.1016/j.jccase.2014.12.002

Table 1.

Main cardiac drugs metabolized by CYP2D6.

β-Blockers Timolol
Propranolol
Metoprolol
Alprenolol
Carvedilol
Bisoprolol



Antiarrhythmic Encainide
Flecainide
Mexiletine
Propafenone

The functional impact of CYP2D6 allele is substrate-dependent and the precise genotype–phenotype correlation can be variable among β-blockers.

Modified from reports 6, 7, 8, 9, 10.