TABLE 1.
Differential expression of mRNAs involved in purine metabolism in livers from mice fed ERD or ERS diets for 4 wk1
| mRNA | ERD | ERS |
|---|---|---|
| Ak1 | 9.0 ± 19.6 | 0.1 ± 0.1 |
| Pde4d | 1.2 ± 0.8 | 0.7 ± 0.1 |
| Nt5c3b | 2.4 ± 0.3* | 1.5 ± 0.1 |
| Ada | 1.0 ± 0.2* | 0.6 ± 0.2 |
| Pole | 0.3 ± 0.1* | 0.2 ± 0.1 |
| Nudt16l1 | 12.1 ± 0.8* | 10.3 ± 1.4 |
| Nme6 | 19.3 ± 3.3* | 25.4 ± 3.2 |
| Entpd7 | 1.1 ± 0.3* | 1.8 ± 0.3 |
| Enpp3 | 9.0 ± 1.4* | 12.5 ± 2.8 |
| Polr1b | 5.0 ± 0.4* | 6.1 ± 0.5 |
| Ak4 | 5.5 ± 0.4* | 7.6 ± 1.9 |
1Values are means ± SD fragments per kilobase million (n = 5 mice/group).
*Significantly different from ERS, P < 0.05. Ada, adenosine deaminase; Ak, adenylate kinase; Enpp3, ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3; Entpd7, ectonucleoside triphosphate diphosphohydrolase 7; ERD, exosome- and RNA-depleted; ERS, exosome– and RNA-sufficient; Nme6, nucleoside diphosphate kinase 6; Nt5c3b, 5′-nucleotidase, cytosolic IIIB; Nudt16l1, (nucleoside diphosphate linked moiety X)-type motif 16-like 1; Pde4d, cAMP-specific phosphodiesterase 4D; Pole, DNA polymerase epsilon subunit 1; Polr1b, DNA-directed RNA polymerase I subunit RPA2.