Table 1.

Studies on the effects of fluid flow on the corneal epithelium.

Author(s)	Methods	Results
Ren and Wilson 1996	In vitro whole-eye perfusion	Shear stress increased apoptosis and terminal differentiation
Ren and Wilson 1997	In vitro whole-eye perfusion	Increased cell shedding with shear force
Kang et al., 2014	Bioreactor flow chamber	Increased proliferation and maintenance of stemness – dependent on flow type
Molladavoodi, S. et al., 2017	Parallel plate flow chamber + Syringe pump	Migratory behavior and wound healing ability affected by shear stress levels
Hampel et al., 2018	IBIDI pump system	Shear stress resulted in less extracellular gaps between cells and increased gene expression of cell junction proteins. Cells did not align in the direction of the flow