Table 5.
Tumors observed in SUFU mutation carriers
| Other Tumors in the 22 MB+ Patients | n Patients (pts) | Age at Diagnosis, y |
|---|---|---|
| Acute myeloid leukemia | 1 | 7.8 |
| Thyroid papillary carcinoma | 1 | 7.7 |
| Sex cord–gonadal stromal tumor | 1 | 13.9 |
| Meningioma | 2 (2 pts) | 10.3 and 33.9 |
| Multiple BCC | 1 | 17.5 |
| Other tumors in 7/34 relatives harboring SUFU germline mutations from 3 families | ||
| BCC | 1 | 71 |
| Meningioma | 1 | 48 |
| Carcinoma: | ||
| Breast cancer | 2 (2 pts) | 37 and 71 |
| Bladder cancer | 1 | 73 |
| Sarcomas1 | 4 (2 pts) | 46, 47, 53, and 71 |
| Neurofibroma | 2 (1 pt) | 46 and 47 |
| Multiple colon polyps | 1 | NA |
| Liver adenoma | 1 | NA |
1 No germline TP53 mutation.