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. 2018 Feb 2;20(8):1055–1067. doi: 10.1093/neuonc/noy012

Fig. 5 .

Fig. 5

Modulation of GCH1 levels in GBM cells affects in vivo survival. (A) Kaplan‒Meier plot showing survival of mice injected orthotopically with 500 cells from the human GBM xenoline D456 with or without GCH1 overexpression (n = 3). Log-rank (Mantel‒Cox) test was employed to calculate P-values. (B) Representative histological images of tumors from panel A; hematoxylin and eosin (H&E) staining, objective 1.25x (left), 20x (right). (C) Tumor growth of orthotopic human D456 xenografts with and without GCH1 overexpression (n = 5), measured by bioluminescent imaging. (D) Representative images of mice in two treatment groups from panel C. (E) Kaplan‒Meier plot showing survival of mice injected orthotopically with 500 cells from the human GBM xenoline D456 with GCH1 knockdown or a non-targeting control (n = 8). (F) Representative histological images of tumors from panel D; H&E staining, objective 1.25x (left), 20x (right).