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. 2018 Nov 28;9:1369. doi: 10.3389/fphar.2018.01369

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Copyright © 2018 van Gastel, Hendrickx, Leysen, Santos-Otte, Luttrell, Martin and Maudsley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of β-arrestin1 and 2 interactome using STRING Interaction Network. To further analyze the networks of (A) β-arrestin1 and (B) β-arrestin2, STRING was used. To increase the stringency of the analysis the following settings were used: for Active Interaction Sources only “Experiments” and “Co-expression” were selected indicating we are only interested in data which is the result of experiments or are known to co-express, this to remove hypothetical data and suggestions. The minimum required interaction score was set to the highest level (0,9), and all unconnected nodes were removed from the network.