FIGURE 3.

Role of β-arrestins in aging through GeneIndexer analysis of interactome metadata. Reanalysis of the obtained interactomes for β-arrestin1 (ARRB1) and β-arrestin2 (ARRB2), using aging-related interrogation terms with GeneIndexer, in a manner similar to that described previously (Chadwick et al., 2012). The following interrogation terms were used: Ageing, Aging, Senescence, Senescent, Elderly, Elder, and Longevity (i.e., long life). These terms (inclusive of most common spellings and synonyms) were used to obtain as much information as possible as human-generated text descriptions using natural language are often variant between research groups/authors. As seen in previous bioinformatics analyses these interrogation terms all give different results. In this figure, it becomes clear that β-arrestin2 has a stronger connection to aging compared to β-arrestin1, with the exception of the interrogation terms Elderly and Elder. For the generation of this figure, the cosine similarity between the top 10 proteins and every interrogation term was averaged in order to create this table. The cosine similarity scores linking the proteins to each word are listed in Supplementary Table S3.