Table 1:
Baseline characteristics of study participants according to coronary artery disease. BMI, body mass index; CAD, coronary artery disease; CRP, C-reactive protein; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; LDL, low density lipoprotein; PVD, peripheral artery disease; ACEI, Angiotensin converting enzyme inhibitor; ARB, Angiotensin Receptor Blocker, PPI, proton pump inhibitor; ESA, erythropoietin stimulating agent; SBP, systolic blood pressure; UPCR, urine protein-creatinine ratio.
| N | With CAD | Without CAD | P value |
|---|---|---|---|
| Anthropometric parameters | |||
| Sample size | 81 | 133 | |
| Age (years) | 68 ± 10 | 55 ± 16 | <0.001 |
| Male Sex (%) | 45 (55.6) | 65 (48.9) | 0.40 |
| White Race (%) | 56 (69.1) | 94 (70.7) | 0.88 |
| SBP (mmHg) | 141 ± 23 | 132 ± 20 | 0.05 |
| DBP (mmHg) | 75 ± 11 | 75 ± 12 | 0.88 |
| Height (m) | 1.71 ± 0.11 | 1.69 ± 0.14 | 0.39 |
| Weight (kg) | 92 ±22 | 89 ± 21 | 0.46 |
| BMI (Kg/m2) | 31 ± 6 | 31 ± 7 | 0.47 |
| Smoking (%) | 9 (11.1) | 12 (9.0) | 0.64 |
| Etiology of CKD | |||
| Hypertension (%) | 21 (25.9) | 23 (17.3) | <0.001 |
| Diabetes (%) | 20 (24.7) | 27 (20.3) | |
| Glomerular (%) | 13 (16.0) | 60 (45.1) | |
| Tubulointerstitial (%) | 2 (2.5) | 5 (3.8) | |
| Others (%) | 25 (30.9) | 18 (13.5) | |
| Comorbidities | |||
| Hypertension (%) | 73 (90.1) | 103 (77.4) | 0.03 |
| Diabetes (%) | 44 (54.3) | 45 (33.8) | 0.004 |
| Stroke (%) | 17 (21.0) | 13 (9.8) | 0.03 |
| Heart failure (%) | 26 (32.1) | 5 (3.8) | <0.001 |
| PVD (%) | 21 (25.9) | 8 (6.0) | <0.001 |
| Arrhythmia (%) | 18 (22.2) | 15 (11.3) | 0.05 |
| Medications | |||
| Statins (%) | 53 (65.4) | 61 (45.9) | 0.007 |
| Fibrates (%) | 8 (9.9) | 10 (7.5) | 0.61 |
| Niacin (%) | 3 (3.7) | 4 (3.0) | 1.000 |
| ACEI/ARB (%) | 60 (74.1) | 90 (67.7) | 0.321 |
| PPI (%) | 27 (33.3) | 31 (23.3) | 0.164 |
| ESA (%) | 10 (12.3) | 9 (6.8) | 0.164 |
| Probiotics/Antibiotics (%) | 2 (2.5) | 3 (2.3) | 1.000 |
| Biochemical parameters | |||
| Albumin (g/dL) | 4.0 ± 0.5 | 4.1 ± 0.4 | 0.65 |
| Hemoglobin (g/dL) | 12.2 ± 1.7 | 11.8 ± 1.7 | 0.08 |
| CRP (mg/dL)† | 1.4 ± 0.4 | 2.6 ± 0.4 | 0.72 |
| Cholesterol (mg/dL) | 160 ± 53 | 174 ± 51 | 0.44 |
| LDL (mg/dL) | 81 ± 38 | 89 ± 41 | 0.23 |
| HDL (mg/dL) | 36 ± 16 | 40 ± 18 | 0.32 |
| Triglycerides (mg/dL) | 157 ± 114 | 167 ± 108 | 0.65 |
| UPCR, median [IQR] | 1.2 [0.4 – 1.9] | 1.0 [0.2 – 1.9] | 0.56 |
| eGFR, mL/min, median [IQR] | 33 [23 to 46] | 38 [26 to 55] | 0.06 |
| eGFR categories | |||
| >60 ml/min (%) | 8 (9.9) | 28 (21.0) | 0.11 |
| 30-59 ml/min(%) | 42 (51.8) | 57 (42.9) | |
| 15-29 ml/min(%) | 26 (32.1) | 35 (26.3) | |
| <15 ml/min(%) | 5 (6.2) | 13 (9.8) | |
†
Sample size for CRP is 12 for CAD and 45 for no CAD.