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Molecular imaging of dopaminergic dysfunction in Parkinson’s disease. PET and SPECT imaging in a PD patient show reduction of VMAT2 activity, DAT availability, and DDC activity compared with a healthy control. DAT = dopamine transporter; DDC = dopa decarboxylase; PD = Parkinson’s disease; PET = positron emission tomography; SPECT = single-photon emission computed tomography; VMAT2 = type 2 vesicular monoamine transporter. Reproduced with permission from Politis M (2014).1
