Table 2.
Antiviral effect of Daio-kanzo-to and its constituents on various influenza viruses.
| IC50 (μg/mL)a | ||||||||
|---|---|---|---|---|---|---|---|---|
| Strain | Subtype | Daio-kanzo-to (TJ-84) | JPb Rhubarb extractc | JP Glycyrrhiza extractd | Sennoside A | Sennoside B | Oseltamivir | Amantadine |
| A/WSN/33 | H1N1 | 10.5±5.5 | 10.4±6.2 | >100 | >173 | >173 | 2.1±0.4 | 80.9±32.6 |
| A/Puerto Rico/8/34 | H1N1 | 8.0±0.2 | 21.6±1.5 | >100 | >173 | >173 | 2.0±0.2 | >188 |
| A/Aichi/2/68 | H3N2 | 15.9±7.3 | 20.9±1.2 | >100 | >173 | >173 | 0.4±0.1 | 0.1±0.0 |
| A/California/7/2009 | H1N1 | 16.7±3.6 | 20.0±4.4 | >100 | >173 | >173 | 0.4±0.0 | >188 |
| A/Virginia/ATCC2/2009 | H1N1 | 20.6±4.2 | 19.1±2.1 | >100 | >173 | >173 | >41.0 | >188 |
a50% inhibitory concentration.
bThe Japanese Pharmacopoeia.
cCommercially available Rhubarb crude drug (Zaiseidoyakuhin Co., Ltd.)
dCommercially available Glycyrrhiza crude drug (Kracie Holdings, Ltd.).