Table 3.

Genotype distributions and allele frequencies of PCSK9 R496W (rs374603772) and D374Y (rs137852912) in the study groups

PCSK9 gene mutation	Genotype/haplotype	Patient group n=200 (100%)	Control group n=201 (100%)	P-value
PCSK9 R496W (rs374603772)	Wild type (CC)	187 (93.5%)	200 (99.5%)	0.005
	Heterozygous (CT)	12 (6%)	1 (0.5%)
	Mutant (TT)	1 (0.5%)	0 (0%)
	C	386	401
	T	14	1
PCSK9 D374Y (rs137852912)	Wild type (GG)	186 (93%)	197 (99.5%)	0.048
	Heterozygous (GA)	13 (6.5%)	4 (2%)
	Mutant (AA)	1 (0.5%)	0 (0%)
	G	385	398
	A	15	4