Table 2.

Subgroup based on different cutoff values of CA 19-9 and CEA.

Outcomes	Group	Ratio of indices and 95% CI	P value	Heterogeneity (%)	P value for heterogeneity	Ratio between subgroups
Sensitivity
Cutoff value of CA 19-9	37 U/ml	1.46 (1.25–1.70)	<0.001	70.1	<0.001	0.55 (0.35–0.87)/0.011
	Others	2.65 (1.72–4.08)	<0.001	0.0	0.977
Cutoff value of CEA	5 ng/ml	1.59 (1.29–1.96)	<0.001	75.9	<0.001	1.10 (0.74–1.64)/0.624
	Others	1.44 (1.03–2.02)	0.034	52.9	0.120
Specificity
Cutoff value of CA 19-9	37 U/ml	1.00 (0.92–1.10)	0.945	67.5	0.001	1.19 (1.04–1.36)/0.011
	Others	0.84 (0.76–0.93)	<0.001	0.0	0.673
Cutoff value of CEA	5 ng/ml	0.96 (0.86–1.06)	0.412	69.8	<0.001	0.94 (0.79–1.12)/0.498
	Others	1.02 (0.89–1.18)	0.757	73.1	0.024
DOR
Cutoff value of CA 19-9	37 U/ml	3.55 (2.16–5.83)	<0.001	49.8	0.030	1.15 (0.29–4.57)/0.848
	Others	3.10 (0.85–11.25)	0.086	38.6	0.202
Cutoff value of CEA	5 ng/ml	3.81 (2.56–5.67)	<0.001	0.0	0.451	1.27 (0.23–7.16)/0.786
	Others	3.00 (0.56–16.21)	0.202	84.3	0.002