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. 2018 Dec 4;9:335. doi: 10.1186/s13287-018-1083-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — BMSCs-CM inhibited silica-induced pulmonary fibrosis in rats. a, c H&E staining, (a) 15 days after instillation; (c) 30 days after instillation. b, d Masson’s trichrome staining. The result revealed that the collagen deposition (blue areas) was significantly increased in the silica group but decrease in the silica + BMSCs-CM group on 15 (b) and 30 days (d). Light micrograph magnification × 100 and × 200. Scale bar, 100 μm and 50 μm. e, f The levels of TGF-β1(e) and content of HYP (f) were increased in the silica group compared with those in the control group, but they were decreased after the addition of BMSCs-CM (p < 0.01). The data were presented as the means ± SD. **p < 0.01 versus the control group; ^##p < 0.01 versus the silica group; ^&p < 0.05 versus the silica + BMSCs group