Fig. 1.

a-d Attenuation of the proliferation of human pancreatic cancer cells compared with that of human normal pancreatic duct epithelial (HDPE) cells by hot water extract of Agaricus blazei Murrill (AbE). Relative proliferation of pancreatic cancer cell lines (MIA PaCa-2, PCI-35, and PK-8) and HPDE treated with AbE at the indicated concentrations, measured by using the MTT assay. The plots represent the average of eight replicates, and the error bars indicate the standard deviation. Y axis denotes a relative growth rate to the mean value of MOCK on Day 1. e Cell death curves of pancreatic cancer cells and HPDE cells treated for 48 h with serial dilutions of AbE. An unpaired t-test with the Holm-Sidak method for multiple comparisons correction was used to compare HPDE to pancreatic cancer cells. ***p < 0.001