Table 2.
Univariate logistic regression analyses between trajectories of hypoxia, hypotension and pupils and 6-month outcomes (measured by GOS) or 6-month mortality
| 6-month outcome | 6-month mortality | |||||||
|---|---|---|---|---|---|---|---|---|
| Favourable | Unfavourable | OR (95% CI) | P-value | Survivors | Deaths | OR (95% CI) | P-value | |
| Number of TBI patientsa | 480 | 415 | – | 637 | 258 | – | ||
| Hypoxia trajectory | < 0.01 | < 0.01 | ||||||
| None | 374 (78%) | 275 (66%) | 1 (Reference) | 482 (76%) | 167 (65%) | 1 (Reference) | ||
| Resolved | 61 (12%) | 89 (21%) | 1.98 (1.38–2.85) | 91 (14%) | 59 (23%) | 1.87 (1.29–2.71) | ||
| Sustained | 5 (1%) | 12 (3%) | 3.26 (1.14–9.37) | 5 (1%) | 12 (4%) | 6.93 (2.41–19.95) | ||
| New event | 2 (1%) | 2 (1%) | 1.36 (0.19–9.72) | 4 (1%) | – | Not estimable | ||
| Missing | 38 (8%) | 37 (9%) | – | 55 (8%) | 20 (8%) | |||
| Hypotension trajectory | < 0.01 | < 0.01 | ||||||
| None | 383 (80%) | 279 (67%) | 1 (Reference) | 500 (78%) | 162 (63%) | 1 (Reference) | ||
| Resolved | 47 (10%) | 67 (16%) | 1.96 (1.31–2.93) | 67 (11%) | 47 (18%) | 2.17 (1.43–3.27) | ||
| Sustained | 11 (2%) | 41 (10%) | 5.12 (2.58–10.13) | 18 (3%) | 34 (13%) | 5.83 (3.21–10.60) | ||
| New event | 11 (2%) | 6 (2%) | 0.75 (0.27–20.5) | 15 (2%) | 2 (1%) | 0.41 (0.09–1.82) | ||
| Missing | 28 (6%) | 22 (5%) | – | 37 (6%) | 13 (5%) | |||
| Pupils trajectory | < 0.01 | < 0.01 | ||||||
| None | 360 (75%) | 180 (43%) | 1 (Reference) | 447 (70%) | 93 (36%) | 1 (Reference) | ||
| Resolved | 28 (6%) | 22 (5%) | 1.57 (0.87–2.82) | 40 (6%) | 10 (4%) | 1.20 (0.58–2.49) | ||
| Sustained | 50 (11%) | 93 (23%) | 3.72 (2.53–5.48) | 87 (14%) | 56 (22%) | 3.09 (2.07–4.63) | ||
| New event | 16 (3%) | 32 (8%) | 4.00 (2.14–7.48) | 26 (4%) | 22 (8%) | 4.07 (2.21–7.49) | ||
| Missing | 26 (5%) | 88 (21%) | – | 37 (6%) | 77 (30%) | |||
aSix-months outcome was not available in 72 (7%) subjects