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a Intratumoral inoculation of an oncolytic virus with transfection and early immune cell recruitment. b Advanced transfection of an oncolytic virus into tumor and niche cells with induction of immune cells resulting in apoptosis, direct cell lysis, niche disruption, and phagocytosis. c Distant tumor immune infiltration induced by local immune conditioning. Blue: immune cells. Red: tumor cells. Orange: oncoviral particles. Green: tumor niche
