Table 2.

SNPs main features of circadian genes tested in this study

Gene	SNP ID	Genotype	Ctrls	Cases	P-val.	Chr	Region	Residue	Ref in cancer
CLOCK	rs1801260	TT	323	92	0.21	4	3′-UTR		[10, 12, 13, 15, 16, 25, 27, 33, 34]
		TC	228	62
		CC	56	8
	rs3736544	GG	241	60	0.72	4	Exon	Asn>Asn
		GA	269	78
		AA	95	24
	rs3749474	CC	259	62	0.45	4	3′-UTR		[10, 15, 16, 33, 35]
		CT	266	80
		TT	83	20
	rs34897046	GG	566	149	0.60	4	Exon	Ser>Cys
		GC	40	13
		CC	1	0
NPAS2	rs895520	GG	211	49	0.20	2	Intron		[10, 26, 27, 36–38]
		GA	294	76
		AA	103	37
	rs2305160	GG	283	75	1.00	2	Exon	Thr>Ala	[10, 14, 15, 21, 23, 26, 27, 34–45]
		GA	264	71
		AA	59	16
PER1	rs3027178	TT	281	84	0.29	17	Exon	Thr>Thr	[10, 17, 28, 46]
		TG	253	64
		GG	76	14
PER2	rs934945	CC	386	118	0.07	2	Exon	Gly>Glu	[10, 17, 24–28, 36, 37, 46]
		CT	206	42
		TT	17	2
	rs7602358	TT	358	87	0.49	2	Intron		[10, 23, 27, 36–38, 40]
		TG	213	64
		GG	38	11
RORA	rs339972	TT	312	97	0.15	15	Intron		[10, 27, 36, 37]
		TC	233	53
		CC	62	12
	rs10519097	CC	422	110	0.67	15	Intron		[10, 27, 36, 37]
		CT	173	50
		TT	14	2
TIMELESS	rs774027	AA	157	44	0.63	12	Exon	Ile > Val	[10, 23, 27, 38]
		AT	301	74
		TT	148	44
	rs3809125	CC	250	70	0.87	12	Upstream
		CT	280	71
		TT	74	20
	rs7302060	TT	181	55	0.53	12	Intron		[10, 20–22]
		TC	304	74
		CC	121	33

Ctrl controls, P-val P value, Chr chromosome, Region Gene region, Residue residue change, Ref in cancer reference in the literature regarding cancer associations