Table 3.
Associations of circadian pathway genes with predisposition to sarcoma under 3 models of inheritance: additive, recessive, dominant
| Gene | SNP ID | Minor allele | Additive | Recessive | Dominant | |||
|---|---|---|---|---|---|---|---|---|
| OR [95% CI] | P-val. | OR [95% CI] | P-val. | OR [95% CI] | P-val. | |||
| CLOCK | rs1801260 | C | 0.74 [0.55–1.00] | 0.05 | 0.40 [0.18–0.88] | 0.02 | 0.79 [0.54–1.14] | 0.20 |
| rs3736544 | A | 1.15 [0.89–1.50] | 0.29 | 1.10 [0.66–1.83] | 0.72 | 1.27 [0.87–1.86] | 0.22 | |
| rs3749474 | T | 1.06 [0.81–1.38] | 0.68 | 0.94 [0.54–1.62] | 0.82 | 1.15 [0.79–1.67] | 0.47 | |
| NPAS2 | rs895520 | A | 1.33 [1.02–1.73] | 0.03 | 1.70 [1.08–2.68] | 0.02 | 1.30 [0.87–1.93] | 0.20 |
| rs2305160 | A | 0.95 [0.72–1.26] | 0.71 | 0.97 [0.52–1.79] | 0.92 | 0.92 [0.64–1.34] | 0.68 | |
| PER1 | rs3027178 | G | 0.80 [0.61–1.06] | 0.12 | 0.72 [0.39–1.35] | 0.31 | 0.76 [0.53–1.10] | 0.15 |
| PER2 | rs934945 | T | 0.65 [0.45–0.94] | 0.02 | 0.48 [0.10–2.25] | 0.35 | 0.63 [0.42–0.95] | 0.03 |
| rs7602358 | G | 1.21 [0.90–1.62] | 0.21 | 1.18 [0.56–2.48] | 0.66 | 1.29 [0.89–1.86] | 0.18 | |
| RORA | rs339972 | C | 0.71 [0.53–0.96] | 0.02 | 0.69 [0.35–1.36] | 0.28 | 0.64 [0.44–0.93] | 0.02 |
| rs10519097 | T | 0.98 [0.68–1.40] | 0.89 | 0.55 [0.12–2.53] | 0.44 | 1.02 [0.69–1.51] | 0.93 | |
| TIMELESS | rs774027 | T | 0.98 [0.76–1.26] | 0.85 | 1.02 [0.67–1.55] | 0.92 | 0.92 [0.61–1.39] | 0.69 |
| rs3809125 | T | 0.92 [0.70–1.20] | 0.52 | 0.89 [0.51–1.55] | 0.67 | 0.89 [0.62–1.30] | 0.55 | |
| rs7302060 | C | 0.98 [0.76–1.27] | 0.89 | 1.03 [0.65–1.62] | 0.91 | 0.94 [0.63–1.39] | 0.75 | |
Italic values indicate statistically significant associations (P < 0.05)
OR [95% CI] Odds Ratio [95% Confidence Interval], P-val. P-value