Table 4.
Association of circadian pathway genes with predisposition to liposarcoma and leiomyosarcoma in subgroups analysis under the additive genetic model
| Gene | SNP ID | Liposarcoma | Leiomyosarcoma | ||
|---|---|---|---|---|---|
| OR [95% CI] | P-val. | OR [95% CI] | P-val. | ||
| CLOCK | rs1801260 | 0.67 [0.46–0.98] | 0.04 | 0.84 [0.56–1.25] | 0.39 |
| rs3736544 | 1.23 [0.88–1.71] | 0.22 | 1.09 [0.76–1.57] | 0.64 | |
| rs3749474 | 1.09 [0.78–1.53] | 0.60 | 1.00 [0.69–1.46] | 0.98 | |
| NPAS2 | rs895520 | 1.26 [0.90–1.75] | 0.18 | 1.44 [0.99–2.09] | 0.05 |
| rs2305160 | 1.01 [0.72–1.43] | 0.95 | 0.88 [0.59–1.32] | 0.54 | |
| PER1 | rs3027178 | 0.68 [0.47–0.98] | 0.04 | 0.96 [0.66–1.41] | 0.85 |
| PER2 | rs934945 | 0.59 [0.37–0.96] | 0.03 | 0.71 [0.42–1.20] | 0.20 |
| rs7602358 | 1.23 [0.85–1.77] | 0.28 | 1.16 [0.77–1.75] | 0.49 | |
| RORA | rs339972 | 0.75 [0.52–1.07] | 0.12 | 0.64 [0.42–0.98] | 0.04 |
| rs10519097 | 0.82 [0.51–1.31] | 0.40 | 1.28 [0.80–2.06] | 0.31 | |
| TIMELESS | rs774027 | 0.98 [0.71–1.35] | 0.90 | 0.95 [0.66–1.35] | 0.76 |
| rs3809125 | 0.99 [0.71–1.38] | 0.95 | 0.79 [0.53–1.16] | 0.23 | |
| rs7302060 | 1.00 [0.72–1.37] | 0.97 | 1.01 [0.70–1.45] | 0.97 | |
Italic values indicate statistically significant associations (P < 0.05)
OR [95% CI] Odds Ratio [95% Confidence Interval], P-val. P-value