Table 2.
Overall Mortality by DAT Definition for Infections Due to Klebsiella pneumoniae or Escherichia coli
| Definition | K. pneumoniae or E. coli Infections | K. pneumoniae Infections Alone | E. coli Infections Alone | |||
|---|---|---|---|---|---|---|
| Studies, n [Ref] |
OR (95% CI) | Studies, n [Ref] |
OR (95% CI) | Studies, n [Ref] |
OR (95% CI) | |
| DAT > 24 h | 5 [17, 21, 23, 24, 29] | 1.24 (0.85–1.80) | 3 [17, 21, 29] | 1.37 (0.73–2.54) | 4 [17, 21, 23, 24] | 1.19 (0.73–1.93) |
| DAT > 48 h | 4 [12, 15, 26, 28] | 1.33 (0.84–2.12) | 1 [26] | a | 2 [15, 28] | 1.86 (1.23–2.80) |
| DAT > 72 h | 4 [13, 18, 19, 25] | 2.12 (0.66–6.79) | 2 [13, 19] | 1.93 (0.25–12.48) | 1 [25] | a |
| DAT > C& SR | 7 [11, 14, 16, 20, 22, 27, 30] | 2.06 (1.36–3.12) | 3 [11, 16, 22] | 1.93 (1.29–2.89) | 1 [20] | a |
| All (Any DAT > 24 or DAT > C& SR) | 20 [11–30] | 1.60 (1.25–2.05) | 9 [11, 13, 16, 17, 19, 21, 22, 26, 29] | 1.53 (1.07–2.17) | 8 [15, 17, 18, 20, 21, 23, 24, 28] | 1.49 (1.10–2.01) |
C& SR culture and susceptibility reporting, DAT delayed appropriate therapy, E. coli Escherichia coli, K. pneumoniae Klebsiella pneumoniae, OR odds ratio
aAnalysis not possible owing to the identification of only 1 study with outcomes reported at the indicated time point for delay