Table 2.
General survival and disease-free survival: univariate and multivariate analysis
| General survival | Disease-free survival | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||||||
| HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | HR | 95% CI | p | |
| Age | 1.06 | 1.04–1.07 | < 0.001 | 1.05 | 1.03–1.07 | < 0.001 | 1 | 0.99–1.02 | 0.62 | |||
| Gender | ||||||||||||
| Male | 1.08 | 0.76-1.52 | 0.67 | 1.01 | 0.69–1.46 | 0.99 | ||||||
| Female | 1 | 1 | ||||||||||
| Location | ||||||||||||
| Right colon | 1.95 | 0.94–4.03 | 0.186 | 1.07 | 0.45–2.57 | 0.41 | ||||||
| Transverse colon | 1.74 | 0.78–3.90 | 0.81 | 0.28–2.34 | ||||||||
| Left colon | 1.12 | 0.46–2.74 | 0.37 | 0.09–1.49 | ||||||||
| Sigmoid colon | 1.89 | 0.82–3.89 | 1.13 | 0.48–2.66 | ||||||||
| Unknown | 1 | 1 | ||||||||||
| Histology | ||||||||||||
| Adenocarcinoma | 0.43 | 0.19–0.98 | 0.12 | 0.30 | 0.11–0.81 | 0.30 | ||||||
| Mucinous Variant | 0.41 | 0.17–0.99 | 0.28 | 0.09–0.85 | ||||||||
| Signet-ring cell | 1 | 1 | ||||||||||
| Grade | ||||||||||||
| Unknown | 1.39 | 0.54–3.59 | 0.22 | 1.04 | 0.31–3.45 | 0.68 | ||||||
| Good | 1.11 | 0.58–2.13 | 0.70 | 0.31–1.55 | ||||||||
| Moderate | 1.49 | 0.81–2.76 | 0.98 | 0.47–2.03 | ||||||||
| Poor | 1 | 1 | ||||||||||
| Major Size (mm) | 1 | 0.99–1.01 | 0.96 | 1 | 0.99–1.01 | 0.399 | ||||||
| Number retrieved LN | 0.97 | 0.95–0.99 | 0.007 | 1.07 | 0.99–1.15 | 0.045 | 0.99 | 0.97–1.02 | 0.99 | |||
| Less than 12 | 1.38 | 1.05–1.82 | 0.023 | 0.90 | 0.62–1.31 | 0.87 | ||||||
| 12 or more | 1 | 1 | ||||||||||
| Number positive LN | 1.09 | 1.05–1.13 | < 0.001 | 1.97 | 1.94–1.99 | 0.027 | 1.02 | 1.01–1.02 | < 0.0001 | 1.08 | 1.01–1.15 | 0.02 |
| Lymph Node Ratio (LNR) | 1.01 | 1–1.02 | < 0.001 | 1.02 | 1.01–1.03 | < 0.0001 | ||||||
| 0–24% | 0.32 | 0.19–0.54 | < 0.001 | 0.20 | 0.10–0.38 | < 0.0001 | ||||||
| 25–60% | 0.60 | 0.34–1.09 | 0.46 | 0.22–0.97 | ||||||||
| > 60% | 1 | 1 | ||||||||||
| Condensed pT (6th Ed.) | ||||||||||||
| pT1–2 | 0.48 | 0.33–0.72 | < 0.001 | 0.46 | 0.31–0.70 | < 0.001 | 2.60 | 1.43–4.73 | < 0.0001 | 2.27 | 1.24–4.15 | 0.008 |
| pT3–4 | 1 | 1 | ||||||||||
| Condensed pN (7th Ed.) | ||||||||||||
| pN0 | 0.47 | 0.33–0.69 | < 0.001 | 0.25 | 0.16–0.40 | < 0.0001 | ||||||
| pN1 | 0.65 | 0.43–0.98 | 0.34 | 0.20–0.58 | ||||||||
| pN2 | 1 | 1 | ||||||||||
| Condensed TNM stage | ||||||||||||
| I | 0.31 | 0.19–0.52 | < 0.001 | 0.21 | 0.10–0.47 | < 0.0001 | ||||||
| II | 0.78 | 0.59–1.03 | 0.63 | 0.42–0.93 | ||||||||
| III | 1 | 1 | ||||||||||
| LODDS | 1.30 | 1.18–1.43 | < 0.001 | 1.43 | 1.11–1.85 | 0.006 | 1.41 | 1.24–1.61 | < 0.0001 | 1.21 | 1.01–1.46 | 0.036 |
| LODDS1 (≤ −2) | 0.28 | 0.14–0.55 | < 0.001 | 0.20 | 0.08–0.51 | 0.005 | ||||||
| LODDS2 (> −2 to ≤1) | 0.46 | 0.23–0.91 | 0.39 | 0.15–0.98 | ||||||||
| LODDS3 (> 1) | 1 | 1 | ||||||||||
| Adjuvant Chemotherapy | ||||||||||||
| Yes | 0.63 | 0.46–0.85 | 0.003 | 1.93 | 1.33–2.81 | < 0.0001 | ||||||
| No | 1 | 1 | ||||||||||
LN Lymph nodes. Multivariate study: variables in continuous format