Table 3.
Risk factors associated with transplant-free 30-day and 90-day mortality in cirrhotic patients with pneumonia
| Variables | 90-day | 30-day | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Model 1: Baseline parameters | Model 1: Baseline parameters | |||||||
| Age | 1.000 (0.982–1.018) | 0.998 | 1.020 (1.001–1.041) | 0.043 | 1.004 (0.981–1.027) | 0.761 | ||
| Multilobar infiltration | 2.474 (1.125–5.443) | 0.024 | 1.954 (0.760–5.027) | 0.164 | ||||
| Bacteremia | 2.88 (1.419–5.843) | 0.003 | 2.651 (1.488–4.724) | 0.001 | 2.293 (0.894–5.877) | 0.084 | 3.037 (1.515–6.090) | 0.002 |
| Inappropriate empirical antibiotic use | 8.894 (4.516–17.516) | <0.001 | 3.126 (1.726–5.662) | <0.001 | 7.645 (3.194–18.295) | <0.001 | 2.326 (1.158–4.673) | 0.018 |
| SIRS | 3.061 (1.662–5.637) | <0.001 | 2.788 (1.278–6.084) | 0.01 | ||||
| Ascites | 2.931 (1.264–6.800) | 0.012 | 1.918 (0.749–4.912) | 0.175 | ||||
| Hepatorenal syndrome | 3.847 (2.238–6.614) | <0.001 | 3.013 (1.494–6.076) | 0.002 | ||||
| Hepatic encephalopathy | 3.534 (2.073–6.023) | <0.001 | 3.416 (1.746–6.683) | <0.001 | ||||
| Model 2: Laboratory exam | Model 2: Laboratory exam | |||||||
| Age | 1.000 (0.982–1.018) | 0.998 | 1.026 (1.006–1.047) | 0.013 | 1.004 (0.981–1.027) | 0.761 | 1.024 (0.997–1.051) | 0.082 |
| WBC (109 /L) | 1.070 (1.048–1.091) | <0.001 | 1.551 (1.358–1.771) | <0.001 | 1.066 (1.040–1.092) | <0.001 | 1.452 (1.257–1.676) | <0.001 |
| Platelet count (109/L) | 0.986 (0.979–0.994) | <0.001 | 0.989 (0.980–0.998) | 0.012 | ||||
| INR | 1.273 (1.190–1.362) | <0.001 | 1.242 (1.163–1.326) | <0.001 | ||||
| Total Bilirubin (mg/dL) | 1.003 (1.001–1.004) | <0.001 | 1.059 (1.021–1.098) | 0.002 | 1.003 (1.001–1.004) | 0.004 | ||
| Hemoglobin (g/L) | 0.985 (0.975–0.996) | 0.006 | 0.991 (0.978–1.004) | 0.159 | ||||
| HCT | 0.938 (0.903–0.976) | 0.001 | 0.955 (0.912–1.000) | 0.052 | ||||
| Creatinine (μmol/L) | 1.003 (1.001–1.004) | <0.001 | 1.003 (1.001–1.004) | 0.004 | ||||
| Glucose | 1.075 (1.046–1.105) | <0.001 | 1.060 (1.019–1.102) | 0.004 | ||||
| Model 3: Severity scores |
Model 3: Severity scores |
|||||||
| CLIF-SOFA score | 1.319 (1.250–1.393) | <0.001 | 1.296 (1.213–1.386) | <0.001 | ||||
| Child-Pugh C grade | 7.024 (3.193–15.450) | <0.001 | 5.198 (2.025–13.344) | 0.001 | ||||
| MELD | 1.096 (1.076–1.117) | <0.001 | 1.086 (1.061–1.112) | <0.001 | ||||
| MELD-Na | 1.066 (1.050–1.083) | <0.001 | 1.062 (1.041–1.083) | <0.001 | ||||
| PSI scores | 1.023 (1.018–1.028) | <0.001 | 1.024 (1.017–1.031) | <0.001 | ||||
| qSOFA≥2 | 6.248 (3.752–10.402) | <0.001 | 8.654 (4.546–16.474) | <0.001 | ||||