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. 2018 Nov 28;5:291. doi: 10.3389/fvets.2018.00291

Table 2.

Summary of NETosis mediated by platelet-neutrophil interactions.

Stimulants Platelet Neutrophil Species Clinical relevance References
ADHESIVE INTERACTIONS
Thrombin LPS P-selectin
?		 ↔
↔		 PSGL-1
LFA-1 (CD11a)		 Mice Sepsis (59)
(27)
LPS ? ↔ LFA-1 (CD11a) Humans Sepsis (27)
TRAP GP1bα ↔ MAC-1 (αMβ2) Mice Acute Lung Injury (64)
LPS Pam3CSK4 Arachidonic acid GP1bα ↔ Beta-2 integrin Humans Sepsis (61)
SOLUBLE INTERACTIONS
LPS TxA2 graphic file with name fvets-05-00291-i0001.jpg ? Mice Transfusion-related acute lung injury (57)
Collagen Thrombin ADP HMGB1 graphic file with name fvets-05-00291-i0001.jpg RAGE Mice Humans Coronary thrombosis (60)
TRAP Platelet Factor 4
(CXCL4) /CCL5
(RANTES) heterodimer		 graphic file with name fvets-05-00291-i0001.jpg ? Mice Acute Lung Injury (64)
LPS Pam3CSK4 arachidonic acid Platelet Factor 4
(CXCL4)		 graphic file with name fvets-05-00291-i0001.jpg ? Humans Sepsis (61)
ADP, fMLP MAC-1 graphic file with name fvets-05-00291-i0002.jpg Vesicles containing arachidonic acid Mice Sepsis associated acute Lung Injury (68)
Citrullinated histones TLR2
TLR4		 graphic file with name fvets-05-00291-i0002.jpg NETs ? (69)

PSGL-1, P-selectin glycoprotein ligand-1; LFA-1, lymphocyte function-associated antigen 1; LPS, Lipopolysaccharide; MAC-1, Macrophage-1 antigen; GP1ba, Glycoprotein 1b alpha; TxA2, Thromboxane A2; HMBG1, High Mobility Group Box 1; RAGE, Advanced Glycation Endproducts; TRAP, Thrombin receptor-activating peptide; Fmlp, N-Formylmethionin-leukcyl-phenylalanine, ?; Unknown.