Fig. 2.
Novelty activations and regression analyses. (A) Group-level contrast depicting increased BOLD responses to novel as compared to familiar scenes in the entire sample of 76 participants (depicted at P < .001 uncorrected, k = 400 voxels). Left panel shows entire activation map as a glass brain. Right panel depicts activation on group template (left is left). (B) Whole-brain regression analysis with CSF total tau levels. CSF total tau levels correlate selectively with novelty responses in the amygdala (left panel) and the hippocampus (right panel). Covariates were MRI sites (6 sites), age, gender, and Aβ42 levels. Abbreviations: CSF, cerebrospinal fluid; MRI, magnetic resonance imaging.