Table 4.

Enzymes of the UPS that mediate GRα protein turnover.

Enzyme	Type of UPS enzyme	Interactions with GRα depend on				Role in GRα turnover	References
		Ligand-binding status		Phosphorylation status
		Unliganded	Liganded	Hypo	Hyper
TSG101	inactive E2 conjugating enzyme	Yes	No	Yes	No	Protects unliganded GRα from turnover	(162)
UbcH7	E2 conjugating enzyme	No	Yes	No	Yes	GC-mediated turnover	(169)
CHIP	E3 ligase	Yes	Yes	Yes	Yes	GC-mediated and basal turnover	(139)
FBXW7α	E3 ligase	No	Yes	No	Yes; at S404	GC-mediated turnover	(136, 167)
Mdm2/Hdm2	E3 ligase	Yes, but requires p53	Yes, but requires p53	Yes	Yes	GC-mediated turnover	(140,144, 155)