Table 1.

Univariate and multivariate Cox regression analyses.

	Dichotomized variables	Recurrence-free survival			Progression-free survival
		Univariate	Multivariatea		Univariate	Multivariatea
		P value	HR (95% CI)	P value	P value	HR (95% CI)	P value
LMPs & LGs (n = 50)
Age	<70 vs ≥70 years	0.500			0.140
Sex	Male vs female	0.764			0.286
Tumor grade	LMP vs LG	0.476			0.404
Pathologic T stage	NA	NA			NA
LN involvement	NA	NA			NA
LVI	NA	NA			NA
AR	0 vs 1+/2+/3+	0.871			0.110
ATF2	0/1+ vs 2+/3+	0.034	2.956 (1.026–8.515)	0.045	0.827
p-ATF2	0 vs 1+	0.564			0.419
p-ERK	0 vs 1+/2+	0.797			0.553
NMI tumors (n = 78)
Age	<70 vs ≥70 years	0.997			0.100
Sex	Male vs female	0.304			0.510
Tumor grade	Lowb vs high	0.037	2.301 (1.053–5.025)	0.037	0.002	10.122 (1.559–63.705)	0.008
Pathologic T stage	pTa vs pT1	0.376			0.150
LN involvement	NA	NA			NA
LVI	NA	NA			NA
AR	0 vs 1+/2+/3+	0.758			0.149
ATF2	0 vs 1+/2+/3+	0.196			0.354
p-ATF2	0 vs 1+	0.928			0.756
p-ERK	0 vs 1+/2+/3+	0.930			0.819
	Dichotomized variables	Progression-free survival			Cancer-specific survival
		Univariate	Multivariatea		Univariate	Multivariatea
		P value	HR (95% CI)	P value	P value	HR (95% CI)	P value
MI tumors (n = 51)
Age	<70 vs ≥70 years	0.835			0.480
Sex	Male vs female	0.545			0.689
Tumor grade	NA	NA			NA
Pathologic T stage	pT2 vs pT3-4	<0.001	5.500 (1.936–15.621)	0.001	0.005	4.913 (1.536–15.719)	0.007
LN involvement	pN0 vs pN1-3	0.136			0.085
LVI	(−) vs (+)	0.256			0.338
AR	0 vs 1+/2+/3+	0.013			0.137
ATF2	0 vs 1+/2+/3+	0.170			0.169
p-ATF2	0 vs 1+	0.004			<0.001	5.317 (1.443–19.594)	0.012
p-ERK	0 vs 1+/2+/3+	0.017	2.727 (0.936–7.945)	0.066	0.004

^aData for each parameter with a P value of >0.1 is not shown. ^bIncludes LMPs and LGs.

CI, confidence interval; HR, hazard ratio; LG, low-grade urothelial carcinoma; LMP, papillary urothelial neoplasm of low malignant potential; LN, lymph node; LVI, lympho-vascular invasion; MI, muscle-invasive; NA, not applicable; NMI, non-muscle-invasive.