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Overall Survival of Metastasized Mice
Mice inoculated with DOX-resistant 4T1 cells were treated with Doxil, PEG- multifunctional envelop-type nano device (MEND) (no RGD modification), and RGD-MEND at 2.0 mg/kg (siRNA) or 3.0 mg/kg (doxorubicin) at days 1, 3, 5, 8, 11, 14, and 20 (n = 4–5).
