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Properties of LNPssPalms modified with different amount of DSG-PEG.
| Amount of PEG | Particle size (nm) | PdI | Zeta potential (mV) |
|---|---|---|---|
| 1.5% DSG-PEG | 117 ± 7 | 0.11 ± 0.01 | −3.6 ± 0.6 |
| 3% DSG-PEG | 117 ± 1 | 0.09 ± 0.01 | −1.5 ± 0.3 |
| 5% DSG-PEG | 114 ± 5 | 0.11 ± 0.02 | −0.4 ± 0.2 |
| 8% DSG-PEG | 119 ± 2 | 0.12 ± 0.02 | −0.3 ± 0.9 |
The composition of the particles was ssPalmO-Paz4-C2/DOPC/Chol = 6/1/3. The indicated mol% of DSG-PEGs were additionally added in lipid composition.
