Table 1.
Clinicopathological features of cases analyzed by NGS.
Group | Num of cases | Age (mean) (years) | Sex | Histology | Fu (range) | FU (event) |
---|---|---|---|---|---|---|
DM-PTC | 29 | 53.0 | 11 M18 F | 17 C-PTC8 TCV-PTC3 FV-PTC1 ST-PTC | 101.7 ms (24–234) | 15 DOD11 AWD2 NED1 NA |
ATC | 18 | 70.6 | 7 M11 F | 18 ATC | 27.9 ms (1–195) | 11 DOD1 AWD2 DOC4 NA |
HA-TC | 47 | 59.7 | 18 M29 F | 17 C-PTC8 TCV-PTC3 FV-PTC1 ST-PTC18 ATC | 69.3 ms (1–234) | 26 DOD12 AWD2 DOC2 NED5 NA |
N0 | 32 | 54.9 | 6 M26 F | 25 C-PTC2 TCV-PTC4 FV-PTC1 ST-PTC | 136.3 ms (77–216) | 30 NED2 NA |
N1 | 34 | 49.1 | 13 M21 F | 24 C-PTC6 TCV-PTC4 FV-PTC | 157.2 ms (85–373) | 5 AWD25 NED4 DOC |
ctrl-PTCs | 66 | 19 M47 F | 49 C-PTC8 TCV-PTC8 FV-PTC1 ST-PTC | 142.1 ms (77–373) | 5 AWD55 NED4 DOC2 NA |
ATC, anaplastic thyroid carcinoma; AWD, alive with disease; C-PTC, classic papillary thyroid carcinoma; ctrl-PTCs, control group (N0 + N1); DM-PTC, distantly metastatic PTC; DOC, dead of other cause; DOD, dead of disease; F, female; FU, follow-up; FV, follicular variant; HA-TC, highly aggressive thyroid carcinoma (DM-PTC + ATC); M, male; ms, months; N0, no lymph nodal involvement at presentation; N1, lymph nodal involvement at presentation; NA, not available; NED, not evidence of disease; ST, solid trabecular; TCV, tall-cell variant.