Table 2.

Sex-Specific Effects of Previously Reported Loci

SNP	Chr	Gene+	Function	CSF Aβ42
				Original β (SE)	Original P	Male β (SE)	Male P	Female β (SE)	Female P	Interaction β (SE)	Interaction P
rs185031519	1	GLIS1	Intergenic	−0.06 (0.01)	2.08×10−8	−0.06 (0.01)	1.06×10−4	−0.06 (0.02)	7.92×10−5	−0.003 (0.02)	0.90
rs316341	6	SERPINB1	Intronic	−0.025 (0.004)	1.72×10−8	−0.02 (0.01)	0.009	−0.03 (0.01)	4.25×10−8	−0.02 (0.01)	0.04*
rs769449	19	APOE	Intronic	−0.10 (0.005)	4.78×10−94	−0.11 (0.01)	3.29×10−53.	−0.09 (0.01)	6.76×10−43	0.01 (0.01)	0.31
SNP	Chr	Gene+	Function	CSF Total Tau
				Original β (SE)	Original P	Male β (SE)	Male P	Female β (SE)	Female P	Interaction β (SE)	Interaction P
rs35055419	3	GMNC	Intergenic	0.04 (0.01)	3.07×10−11	0.03 (0.01)	0.0003	0.05 (0.01)	2.57×10−8	0.02 (0.01)	0.17
rs769449	19	APOE	Intronic	0.08 (0.01)	4.05×10−29	0.07 (0.01)	4.41×10−12	0.09 (0.01)	5.58×10−20	0.02 (0.01)	0.10
SNP	Chr	Gene+	Function	CSF Phosphorylated Tau
				Original β (SE)	Original P	Male β (SE)	Male P	Female β (SE)	Female P	Interaction β (SE)	Interaction P
rs9527039	13	PCDH8	Intergenic	−0.06 (0.01)	5.95×10−9	−0.05 (0.01)	0.002	−0.08 (0.02)	5.64×10−7	−0.03 (0.02)	0.15
rs12961169	18	CTDP1	Intergenic	0.05 (0.01)	5.12×10−10	0.05 (0.01)	1.16×10−5	0.05 (0.01)	3.58×10−5	−0.004 (0.02)	0.81
rs35055419	3	GMNC	Intergenic	0.04 (0.01)	7.62×10−10	0.03 (0.01)	0.0002	0.04 (0.01)	1.48×10−6	0.01 (0.01)	0.45
rs514716	9	GLIS3	Intronic	−0.05 (0.01)	2.94×10−8	−0.04 (0.01)	0.0004	−0.05 (0.01)	3.45×10−5	−0.01 (0.02)	0.51
rs769449	19	APOE	Intronic	0.08 (0.01)	5.30×10−33	0.07 (0.01)	5.83×10−14	0.09 (0.01)	4.31×10−22	0.02 (0.01)	0.10

Boldface font signifies genome-wide significant association

^*indicates interaction p<0.05.

⁺Gene listed is the closest gene and may not be the functional gene.