Table 4.
Replication of Sex-Specific Effects in Autopsy Samples from ROS/MAP
| SNP | Chr | Gene+ | Function | Amyloid Burden | |||||
|---|---|---|---|---|---|---|---|---|---|
| Male β (SE) |
Male P | Female β (SE) |
Female P | Interaction β (SE) |
Interaction P | ||||
| rs316341 | 6 | SERPINB1 | Intronic | 0.19 (0.10) |
0.06 | −0.001 (0.07) |
0.99 | −0.18 (0.12) |
0.14 |
| rs13115400 | 4 | LINC00290 | Intergenic | 0.02 (0.09) |
0.79 | 0.07 (0.06) |
0.24 | 0.06 (0.11) |
0.59 |
| SNP | Chr | Gene+ | Function | Neuronal Neurofibrillary Tangles | |||||
|
Male β (SE) |
Male P |
Female β (SE) |
Female P |
Interaction β (SE) |
Interaction P | ||||
| rs1393060 | 3 | GMNC | Intergenic | −0.01 (0.10) |
0.93 |
0.14 (0.07) |
0.047 | 0.16 (0.12) |
0.18 |
Boldface font signifies p<0.05.
+
Gene listed is the closest gene and may not be the functional gene.