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BETi and HDACi reduce c-Myc and downstream proliferative drivers.
(A and B) mRNA was prepared from CTCL cells under different conditions and used for qRT-PCR. Quantification: normalization to GAPDH mRNA. (C and D) Immunoblot analysis of c-Myc CyclinD1, CDKN1A, and CDKN1B protein in three CTCL cell lines; β-actin served as a loading control; cells were treated with JQ1 (1 μM), SAHA (1 μM), or combination (1 μM each). Mean ± SEM; n = 3, *P < .05, **P < .01 compared to vehicle control.
