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BETi and HDACi reduce NFkB and cytokine receptors.
(A) Immunoblot analysis of NFkB1, NFkB2, and IkBα protein in three CTCL cell lines; β-actin served as a loading control. (B) mRNAs were prepared from CTCL cells under different conditions and used for qRT-PCR. Quantification: normalization to GAPDH mRNA; Cells were treated with JQ1 (1 μM), SAHA (1 μM), or combination (1 μM each). Mean ± SEM; n = 3, *P < .05, **P < .01 compared to vehicle control.
