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. 2018 Dec 4;21(1):82–92. doi: 10.1016/j.neo.2018.11.006

Figure 6.

Figure 6

BETi and HDACi induce marked apoptosis in CTCL cell lines and leukemic CTCL blood samples.

Quantification of flow cytometric analysis of apoptotic cell death (early and late apoptosis, right two quadrants of each Annexin V/PI scatter plot panel) after 3 and 4 days of CPI-0610 (125 nM), I-BET762 (125 nM), OTX015 (125 nM), JQ1 (1 μM), SAHA (1 μM), Romidepsin (1 nM), or combination treatment. (A and B) Five CTCL cell lines; (C and D) 4 leukemic CTCL blood samples. Data are presented as mean ± SEM, n = 3, “*” means combination group compared to HDACi alone group respectively. *P < .05, **P < .01.