Table 1.
Mouse and human innate lymphoid cell (ILC) phenotypes
| Group | Progenitor | Mouse |
Human |
Cytokines | ||
|---|---|---|---|---|---|---|
| Cell-surface molecules | TFs | Cell-surface molecules | TFs | |||
| 1 | cNK | CD122, CD49b, NK1.1, NKG2A, NKp46, IL-12RB1, CD25, KLRG1 | EOMES T-bet | CD122, NKG2A, NKp46, NKp44+/−, IL-12RB1, CD25, KLRG1 | EOMES T-bet | IFN-γ, TNF |
| ieILC1 | CD122, CD90, NK1.1, NKG2A, NKp46, IL-12RB1 | EOMES T-bet | CD122, NKG2A, NKp46, NKp44, IL-12RB1 | EOMES T-bet | IFN-γ | |
| ILC1 | CD127, CD122, CD90, CD49a, NK1.1, NKp46, IL-12RB1 | T-bet | CD127, CD161, IL-12RB1, KLRG1, ICOS, CD4+/− | T-bet | IFN-γ, TNF | |
| 2 | ILC2 | CD127, CD90, CRTH2, CD117+/−, CD25, ST2, TSLPR, IL-17RB, KLRG1, ICOS, MHCII | GATA3 | CD127, CD161, CRTH2, CD117+/−, CD25, ST2, TSLPR, IL17RB, KLRG1, ICOS, CCR6, MHCII | GATA3 | IL-4, IL-5, IL-9, IL-13 |
| 3 | ILC3 NCR+ | CD127, CD90, CD117, NKp46, CD25, ICOS, IL-23R, L-1R1 | RORγt T-bet | CD127, CD161, CD117, NKp46, NKp44, IL-12RB1, CD25, ICOS, CCR6, IL-23R, IL-1R1, MHCII | RORγt | IL-22 |
| ILC3 NCR− | CD127, CD90, CD25, ICOS, IL-23R, IL-1R1, MHCII | RORγt T-bet | CD127, CD161, CD117, IL-12RB1, CD25, ICOS, CCR6, IL-23R, IL-1R1 | RORγt | IL-17A | |
| LTi | CD127, CD90, CD117, CD25, CCR6, IL-23R, IL-1R1, MCHII, CD4+/−, NRP1 | RORγt | CD127, CD161, CD117, CD25, CCR6, IL-23R, IL-1R1, NRP1 | RORγt | IL-17A, IL-22 | |
ICOS, Inducible T-cell costimulator; KLRG1, killer cell lectin-like receptor subfamily G member 1; NCR, natural cytotoxicity receptor; GATA3, GATA-binding factor 3; EOMES, eomesodermin; TSLPR, thymic stromal lymphopoietin receptor; TFs; transcription factors; IFN, interferon; TNF, tumor necrosis factor; IL, interleukin; RORγt, RAR-related orphan receptor γt.